The molecular and cellular events in angiogenesis have been elucidated, and defects in this process are present in chronic wounds. Based on this knowledge, new wound healing strategies are emerging to deliver growth factors to the wound bed. Surgeons and other wound-care specialists can use this knowledge to identify defects and select interventions that may promote improved wound granulation and healing. Angiogenesis therapies. Concepts, clinical trials, and considerations for new drug development. The new angiotherapy. Totowa: Humana Press; Clinical applications of research on angiogenesis.
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PLoS One ;9:e Microangiopathy of cutaneous blood and lymphatic capillaries in chronic venous insufficiency CVI.officegoodlucks.com/order/9/3663-buscar-celular.php
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While VEGF is a primary mediator of angiogenic responses, bFGF is also one of potent angiogenesis inducers to stimulate the vascular endothelial mitogenesis and is often involved in pathologic angiogenesis. Tumor angiogenesis involves complex and multiple vascular endothelial responses as well as contributions from tumor cells. The endothelial responses include angiogenic factor-stimulated changes in the vascular endothelial permeability, degradation of the basement membrane by metalloproteases, migration, remodeling and proliferation of endothelial cells to form capillary tubes, and other processes.
On the other hand, tumor cells or host stromal cells express VEGF induced by hypoxia and other autocrine or paracrine growth factors  ,  ,  ,  ,  ,  ,  to stimulate endothelial progenitor cells for angiogenesis. Interruptions of one or more steps in these processes can negatively affect angiogenesis and inhibit early malignant lesions to lower the cancer risk  VEGF expression is mediated by the phosphoinositide 3-kinase PI3K pathway in endothelial cells .
Also, PI3K pathway reveals its effects through its downstream kinase AKT to regulate various cellular processes including angiogenesis .
Paeonol oxime 1-[2-hydroxymethoxy phenyl] ethanone oxime; PO was derived from paeonol 2-hydroxy, 4-methoxy acetophenone , which has been shown to be anti-angiogenic  Fig. We designed and synthesized PO so that it also shares some similarity with acetylsalicylic acid Fig. We also explored the potential signaling events affected by PO in angiogenic HT cells by Western blotting and immunofluorescence microscopy.
Paeonol oxime PO 1-[2-hydroxymethoxy phenyl] ethanone oxime was synthesized from paeonol.